An antimicrotubule agent that binds to β-tubulin with a similar order of magnitude as the binding of paclitaxel to β-tubulin (IC50s = 2.3 and 3.6 µM

Epothilone A – 1 mg

Brand:
Cayman
CAS:
152044-53-6
Storage:
-20
UN-No:
Non-Hazardous - /

Epothilone A (Epo A) is a biologically active macrolide produced from the fermentation of the soil bacteria S. cellulosum that was discovered as a potent antimicrotubule agent.{26908,19711,19714} In competition assays, epo A binds to β-tubulin with a similar order of magnitude as the binding of paclitaxel (Item No. 10461) to β-tubulin (IC50s = 2.3 and 3.6 µM, respectively).{26908,19711,19714,19713} Epo A is cytotoxic to human T-24 bladder carcinoma cells (IC50 = 0.05 µM in vitro) but has poor pharmacological properties and is 2-fold less potent in stabilizing microtubules compared to epothilone B (Item No. 10924).{26908}  

 

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Description

An antimicrotubule agent that binds to β-tubulin with a similar order of magnitude as the binding of paclitaxel to β-tubulin (IC50s = 2.3 and 3.6 µM, respectively); cytotoxic to human T-24 bladder carcinoma cells (IC50 = 0.05 µM in vitro)

Formal name: (1S,16R)-7S,11S-dihydroxy-8,8,10R,12S-tetramethyl-3S-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione

Synonyms:  Epo A

Molecular weight: 493.7

CAS: 152044-53-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Microtubule Dynamics||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cancer|Cell Death||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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