An inhibitor of CK1α

Epiblastin A – 5 mg

Brand:
Cayman
CAS:
16470-02-3
Storage:
-20
UN-No:
Non-Hazardous - /

Epiblastin A is an ATP-competitive inhibitor of the casein kinase 1 (CK1) isoforms α, δ, and ε (IC50s = 8.9, 0.5, and 4.7 μM, respectively).{37345} It is selective for CK1α, CK1δ, and CK1ε at concentrations below 10 μM, however, it also inhibits BRSK1, EEF2K, EGFR, MNK-2, and RIPK2 (IC50s = 24-45 μM). Epiblastan A reduces immunoprecipitation of CK1α, CK1δ, and CK1ε from HCT116 cell lysates in a concentration-dependent manner. It induces reprogramming of mouse epiblast stem cells (mEpiSCs) into embryonic stem cells (ESCs) 8-fold more efficiently than triamterene (Item Nos. 21242 | 22486).  

 

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Description

An inhibitor of CK1α, CK1δ, and CK1ε (IC50s = 8.9, 0.5, and 4.7 μM, respectively); reduces immunoprecipitation of CK1α, CK1δ, and CK1ε from HCT116 cell lysates in a concentration-dependent manner; induces reprogramming of mEpiSCs into ESCs

Formal name: 6-(3-chlorophenyl)-2,4,7-pteridinetriamine

Synonyms: 

Molecular weight: 287.7

CAS: 16470-02-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|CaMKs||Product Type|Biochemicals|Kinase Inhibitors|CK1||Product Type|Biochemicals|Kinase Inhibitors|EGFR/ErbB/HER Family||Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|ERK/MAPK Signaling||Research Area|Cell Biology|Stem Cell Research|Reprogramming

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