A selective IDO1 inhibitor (IC50 = 7.1 nM in HeLa cells); promotes T and natural killer-cell growth

Epacadostat – 10 mg

Brand:
Cayman
CAS:
1204669-58-8
Storage:
-20
UN-No:
Non-Hazardous - /

Epacadostat is an inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1) with an IC50 value of 7.1 nM in HeLa cells that demonstrates little activity against the related enzymes IDO2 or tryptophan 2,3-dioxygenase (TDO).{29738} It has been shown to promote T and natural killer-cell growth, to increase IFN-γ production, and to reduce conversion to regulatory T (Treg)-like cells in a coculture system of human allogeneic lymphocytes with either dendritic cells or tumor cells.{29738} Epacadostat can also inhibit tumor growth in tumor-bearing mice in a lymphocyte-dependent manner.{29738}  

 

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Description

A selective IDO1 inhibitor (IC50 = 7.1 nM in HeLa cells); promotes T and natural killer-cell growth, increases IFN-γ production, and reduces conversion to Treg-like cells in a coculture system of human allogeneic lymphocytes with either dendritic cells or tumor cells; inhibits tumor growth in tumor-bearing mice in a lymphocyte-dependent manner

Formal name: [C(Z)]-4-[[2-[(aminosulfonyl)amino]ethyl]amino]-N-(3-bromo-4-fluorophenyl)-N’-hydroxy-1,2,5-oxadiazole-3-carboximidamide

Synonyms:  INCB024360

Molecular weight: 438.2

CAS: 1204669-58-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity

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