Description
The biological effects of prostaglandin E2 (PGE2) are mediated through interaction with four distinct membrane-bound G protein-coupled EP receptors: EP1, EP2, EP3, and EP4.{6742,9114} Binding of PGE2 to the EP4 receptor causes an increase in intracellular cyclic AMP and subsequent relaxation of smooth muscle.{3164,3186,2035,3185} In addition to sequence differences, EP4 receptors are distinguished from EP2 receptors by their insensitivity to the EP2 receptor selective agonist butaprost.{2035,3178} The EP4 receptor is expressed in multiple human tissues including kidney, small intestine, thymus, ileum, uterus, and lung, as well as in peripheral blood leukocytes.{3164,3186} The receptor is also expressed in cultured human blood cell lines of monocytoid (U937 and THP-1) and lymphoid (MOLT-4, Jurkat, and Raji) origin.{3185}
Synonyms: Prostaglandin E2 Receptor 4
Immunogen: Synthetic peptide from the C-terminal cytoplasmic region of human EP4 receptor
Formulation: 500 µl of peptide affinity-purified antibody conjugated to PE
Isotype:
Applications: FC and IF
Origin: Animal/Rabbit
Stability: 365 days
Application|Flow Cytometry||Application|Immunofluorescence||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway
