An inhibitor of IDO-1 (IC50 = 0.15 µM); selective for IDO-1 over IDO-2 up to a concentration of 200 µM; inhibits IDO-1-mediated production of kynurenine induced by IFN-γ in HeLa cells (IC50 = 1.8 µM); inhibits IDO-1-mediated production of kynurenine induced by LPS and IFN-γ in THP-1 cells and human-derived whole blood ex vivo (IC50s = 1.7 and 4.7 µM

EOS200271 – 10 mg

Brand:
Cayman
CAS:
198474-05-4
Storage:
-20
UN-No:
- /

EOS200271 is an inhibitor of indoleamine 2,3-dioxygenase 1 (IDO-1; IC50 = 0.15 µM for the human enzyme).{40577} It is selective for IDO-1 over IDO-2 up to a concentration of 200 µM for the human recombinant enzymes. EOS200271 inhibits IDO-1-mediated production of kynurenine induced by IFN-γ in HeLa cells (IC50 = 1.8 µM) and by LPS and IFN-γ in THP-1 cells and human-derived whole blood ex vivo (IC50s = 1.7 and 4.7 µM, respectively).  

 

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SKU: 25003 - 10 mg Category:

Description

An inhibitor of IDO-1 (IC50 = 0.15 µM); selective for IDO-1 over IDO-2 up to a concentration of 200 µM; inhibits IDO-1-mediated production of kynurenine induced by IFN-γ in HeLa cells (IC50 = 1.8 µM); inhibits IDO-1-mediated production of kynurenine induced by LPS and IFN-γ in THP-1 cells and human-derived whole blood ex vivo (IC50s = 1.7 and 4.7 µM, respectively)

Formal name: 3-(5-fluoro-1H-indol-3-yl)-2,5-pyrrolidinedione

Synonyms:  PF-06840003

Molecular weight: 232.2

CAS: 198474-05-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation|Innate Immunity

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