An essential ceramide for prevention of epidermal water loss; found in the outer epidermis of mammals; consecutive regio- and stereospecific oxygenation of the linoleate portion by 12(R)-LO and eLOX3 is essential for the maintenance of the epidermal barrier to prevent water loss

EOS (d18:1/32:1/18:2) – 500 µg

Brand:
Cayman
CAS:
1318771-31-1
Storage:
-20
UN-No:
Non-Hazardous - /

EOS is a ceramide found in the outer layer of the epidermis in mammals.{34500} It is comprised of an ω-hydroxy very long-chain ceramide (C28-36) esterified to the essential fatty acid linoleic acid (Item No. 90150). The consecutive regio- and stereospecific oxygenation of the linoleate portion of EOS by 12(R)-lipoxygenase (12(R)-LO) and eLOX3 is essential for the maintenance of the epidermal barrier to prevent water loss. Following oxygenation, the oxidized linoleate is hydrolyzed, leaving the ω-hydroxy end of the very long-chain fatty acid to covalently bind the protein layer, forming the corneocyte lipid envelope and sealing the gap between the extracellular lipid lamellae and the cornified cell envelope of the corneocyte.  

 

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Description

An essential ceramide for prevention of epidermal water loss; found in the outer epidermis of mammals; consecutive regio- and stereospecific oxygenation of the linoleate portion by 12(R)-LO and eLOX3 is essential for the maintenance of the epidermal barrier to prevent water loss

Formal name: 9Z,12Z-octadecadienoic acid, (10Z)-32-[[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]amino]-32-oxo-10-dotriaconten-1-yl ester

Synonyms:  C52:3 EOS (18:1/32:1(22 Z)w18:2(9Z,12Z)|Esterified ω-hydroxyacyl Sphingosine

Molecular weight: 1,038.80

CAS: 1318771-31-1

Purity: ≥95%

Formulation: A solution in dichloromethane

Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Lipid Biochemistry|Lipoxygenase Pathways||Research Area|Lipid Biochemistry|Sphingolipids

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