An essential ceramide for prevention of epidermal water loss; found in the outer epidermis of mammals; consecutive regio- and stereospecific oxygenation of the linoleate portion by 12(R)-LO and eLOX3 is essential for the maintenance of the epidermal barrier to prevent water loss; has been found in intact and desquamated human stratum corneum as well as porcine epidermis

EOS (d18:1/30:0/18:2) – 1 mg

Brand:
Cayman
CAS:
97040-38-5
Storage:
-20
UN-No:
Non-Hazardous - /

EOS is a ceramide found in the outer layer of the epidermis in mammals.{34500} It is comprised of an ω-hydroxy very long-chain ceramide (C28-36) esterified to the essential fatty acid linoleic acid (Item No. 90150). The consecutive regio- and stereospecific oxygenation of the linoleate portion of EOS by 12(R)-lipoxygenase (12(R)-LO) and eLOX3 is essential for the maintenance of the epidermal barrier to prevent water loss. Following oxygenation, the oxidized linoleate is hydrolyzed, leaving the ω-hydroxy end of the very long-chain fatty acid to covalently bind the protein layer, forming the corneocyte lipid envelope and sealing the gap between the extracellular lipid lamellae and the cornified cell envelope of the corneocyte. EOS (d18:1/30:0/18:2) is a sphingolipid that has been found in intact and desquamated human stratum corneum as well as porcine epidermis.{41643,41644} [Matreya, LLC. Catalog No. 2084]  

 

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SKU: 24394 - 1 mg Category:

Description

An essential ceramide for prevention of epidermal water loss; found in the outer epidermis of mammals; consecutive regio- and stereospecific oxygenation of the linoleate portion by 12(R)-LO and eLOX3 is essential for the maintenance of the epidermal barrier to prevent water loss; has been found in intact and desquamated human stratum corneum as well as porcine epidermis

Formal name: 30-[[2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]amino]-30-oxotriacontyl ester, 9,12-octadecadienoic acid

Synonyms:  C48:2 EOS (d18:1/30:0w18:2 (9Z,12Z))|N-(30-linoleoyloxy-triacontanoyl)-Sphingosine

Molecular weight: 1,012.70

CAS: 97040-38-5

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Lipids|Sphingolipids||Research Area|Lipid Biochemistry|Sphingolipids

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