A non-enzymatic

ent-8-iso-15(S)-Prostaglandin F2α – 25 µg

Brand:
Cayman
CAS:
214748-66-0
Storage:
-20
UN-No:
De Minimis - 1648 / 3

Isoprostanes are produced by the non-enzymatic, free radical peroxidation of phospholipid-esterified arachidonic acid. They have been used as biomarkers of oxidative stress, but they also have been found to have potent biological activity. ent-8-iso-15(S)-Prostaglandin F2α (ent-8-iso-15(S)-PGF2α) is a potent vasoconstrictor of porcine retinal and brain microvessels with EC50 values of 15 and 24 nM, respectively.{14005} This isoprostane is about ten-fold more potent than 8-iso-PGF2α in a whole blood platelet aggregation inhibition assay.{14928}  

 

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SKU: 10010380 - 25 µg Category:

Description

A non-enzymatic, free radical peroxidation product of arachidonic acid; acts as a potent vasoconstrictor of porcine retinal and brain microvessels with EC50 values of 15 and 24 nM, respectively; approximately ten-fold more potent than 8-iso-PGF2α in a whole blood platelet aggregation inhibition assay

Formal name: 9β,11β,15S-trihydroxy-(12β)-prosta-5Z,13E-dien-1-oic acid

Synonyms:  ent-15-epi-F2t-Isoprostane|ent-8-iso-15-epi-PGF2α

Molecular weight: 354.5

CAS: 214748-66-0

Purity: ≥98%

Formulation: A solution in acetonitrile

Product Type|Biochemicals|Lipids|Isoprostanes||Product Type|Biochemicals|Lipids|Prostaglandins||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Vasculature|Vasoconstriction||Research Area|Lipid Biochemistry|Reactive O2/N2 Pathways||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation

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