A fluoroquinolone that prevents bacterial growth by interfering with DNA replication

Enoxacin – 1 g

Brand:
Cayman
CAS:
74011-58-8
Storage:
-20
UN-No:
Non-Hazardous - /

Enoxacin is a fluoroquinolone that prevents bacterial growth by interfering with DNA replication, inhibiting bacterial DNA gyrase (IC50 = 126 µg/ml) and topoisomerase IV (IC50 = 26.5 µg/ml).{27493} It demonstrates broad-spectrum antibacterial activity against many Gram-positive and Gram-negative bacteria.{27493} Its ability to bind to TAR RNA-binding protein 2, a microRNA biosynthesis protein, has been used to enhance the production of microRNAs with tumor suppressor functions to generate tumor-specific growth inhibitory effects in cancer models.{27668}  

 

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Description

A fluoroquinolone that prevents bacterial growth by interfering with DNA replication, inhibiting bacterial DNA gyrase (IC50 = 126 µg/ml) and topoisomerase IV (IC50 = 26.5 µg/ml); used to enhance the production of microRNAs with tumor suppressor functions to generate tumor-specific growth inhibitory effects in cancer models

Formal name: 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid

Synonyms:  NSC 629661

Molecular weight: 320.3

CAS: 74011-58-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Quinolones & Fluoroquinolones||Product Type|Biochemicals|Small Molecule Inhibitors|Topoisomerases||Research Area|Cancer||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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