A cyclohexadepsipeptide that has been shown to induce apoptosis in several cancer lines (EC50s ≤ 10 µM) and to decrease the activation of the cell proliferation kinase

Enniatin B1 – 1 mg

Brand:
Cayman
CAS:
19914-20-6
Storage:
-20
UN-No:
De Minimis - 3462 / 6.1

Enniatins are cyclohexadepsipeptides commonly isolated from fungi and are known to have antibiotic properties. Many act as ionophores, forming pores in cellular membranes to allow selective ion transport.{24952,24954} Enniatin B1 is one of four major analogs of the enniatin complex (Item No. 9002040). It has been shown to induce apoptosis in several cancer lines (EC50s ≤ 10 µM) and to decrease the activation of the cell proliferation kinase, ERK (p44/p42).{24949} Enniatin B1 also inhibits the multi-drug resistance transporter Pdr5p from S. cerevisiae and has been used to examine drug resistance mechanisms.{24951}  

 

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Description

A cyclohexadepsipeptide that has been shown to induce apoptosis in several cancer lines (EC50s ≤ 10 µM) and to decrease the activation of the cell proliferation kinase, ERK (p44/p42); inhibits the multi-drug resistance transporter Pdr5p from S. cerevisiae

Formal name: cyclo[(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-valyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-valyl]

Synonyms: 

Molecular weight: 653.9

CAS: 19914-20-6

Purity: ≥99%

Formulation: A powder

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|ERK/MAPK Signaling

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