An analog in the enniatin complex; induces apoptosis in cancer cells (EC50 = 5 µM in H4IIE rat hepatoma cells)

Enniatin A1 – 1 mg

Brand:
Cayman
CAS:
4530-21-6
Storage:
-20
UN-No:
De Minimis - 3462 / 6.1

Enniatins are cyclohexadepsipeptides commonly isolated from fungi that are known to have antibiotic properties and to induce apoptosis in several cancer lines.{24952} Many function as ionophores, forming pores in cellular membranes to allow selective ion transport.{24952,24954} Enniatin A1 is one of four major analogs in the enniatin complex (Item No. 9002040 class). Its ionophoric activity has been described.{24954} Additionally, enniatin A1 has been found to induce apoptosis in cancer cells (EC50 = 5 µM in H4IIE rat hepatoma cells), decreasing the activation of the cell proliferation kinase, ERK (p44/p42) and inhibiting TNF-α-induced NF-κB activation.{24949}  

 

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Description

An analog in the enniatin complex; induces apoptosis in cancer cells (EC50 = 5 µM in H4IIE rat hepatoma cells), decreasing the activation of ERK (p44/p42) and inhibiting TNF-α-induced NF-κB activation

Formal name: cyclo[(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-valyl]

Synonyms: 

Molecular weight: 667.9

CAS: 4530-21-6

Purity: ≥99%

Formulation: A powder

Product Type|Biochemicals|Antibiotics|Ionophores||Product Type|Biochemicals|Ion Channel Modulation||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Peptides||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|ERK/MAPK Signaling||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Immunology & Inflammation

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