Description
A biomimetic peptide inhibitor of HIV-1 fusion with CD4+ cells; inhibits HIV-1 infectivity of HeLa cells stably expressing CD4 by the HXB2 strain (IC50 = 692 pM) and by clinical isolates (IC90s = 6.1-61 nM) in a single-cycle infectivity assay; inhibits genomic integration of HIV-1 into human intraepithelial vaginal cells and PBMCs (IC50s = 51.2 and 13.58 μM, respectively); binds to a recombinant molecular mimic of HIV-1 glycoprotein gp41 (Kd = 32 nM); binds to recombinant FPRs expressed in rat basophilic leukemia cells (IC50 = 5 nM) and attracts and activates human peripheral blood phagocytes, but not T lymphocytes, in vitro (100 nM)
Formal name: N-acetyl-L-tyrosyl-L-threonyl-L-seryl-L-leucyl-L-isoleucyl-L-histidyl-L-seryl-L-leucyl-L-isoleucyl-L-α-glutamyl-L-α-glutamyl-L-seryl-L-glutaminyl-L-asparaginyl-L-glutaminyl-L-glutaminyl-L-α-glutamyl-L-lysyl-L-asparaginyl-L-α-glutamyl-L-glutaminyl-L-α-glutamyl-L-leucyl-L-leucyl-L-α-glutamyl-L-leucyl-L-α-aspartyl-L-lysyl-L-tryptophyl-L-alanyl-L-seryl-L-leucyl-L-tryptophyl-L-asparaginyl-L-tryptophyl-L-phenylalaninamide
Synonyms:
Molecular weight: 4,491.90
CAS: 159519-65-0
Purity: ≥95%
Formulation: A crystalline solid
Product Type|Biochemicals|Antivirals|Entry/fusion Inhibitors||Product Type|Biochemicals|Peptides||Research Area|Immunology & Inflammation|Innate Immunity|Phagocytosis||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS
