A cell-permeable inhibitor of exocytosis and endosomal recycling in plant and mammalian cells; binds the EXO70 subunit of the exocyst complex (Kd = 253 μM

Endosidin 2 – 5 mg

Brand:
Cayman
CAS:
1839524-44-5
Storage:
-20
UN-No:
Non-Hazardous - /

Endosidin 2 (ES2) is a cell-permeable benzylidene-benzohydrazide that binds to the exocyst component of the 70 kDa (EXO70) subunit of the exocyst complex (Kd = 253 μM, EXO70A1).{38068} ES2 binding inhibits exocytosis and endosomal recycling in plant and mammalian cells. ES2 disrupts protein trafficking between the endosome and plasma membrane, which enhances trafficking to the vacuole for degradation. It also inhibits recycling of endocytosed transferrin to the plasma membrane in HeLa cells and can target multiple isoforms of mammalian EXO70, resulting in misregulation of exocytosis.  

 

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Description

A cell-permeable inhibitor of exocytosis and endosomal recycling in plant and mammalian cells; binds the EXO70 subunit of the exocyst complex (Kd = 253 μM, EXO70A1); disrupts protein trafficking between the endosome and plasma membrane; enhances trafficking to the vacuole for degradation; inhibits recycling of endocytosed transferrin in HeLa cells ,

Formal name: 3-fluoro-benzoic acid, (2E)-2-[(4-hydroxy-3-iodo-5-methoxyphenyl)methylene]hydrazide

Synonyms:  ES2

Molecular weight: 414.2

CAS: 1839524-44-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking

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