The active metabolite of the ACE inhibitor

Enalaprilat (hydrate) – 5 mg

Brand:
Cayman
CAS:
84680-54-6
Storage:
-20
UN-No:
Non-Hazardous - /

Angiotensin-converting enzyme (ACE) converts angiotensin I to angiotensin II, a peptide hormone that impacts vascular smooth muscle tone and renal salt exchange, driving hypertension. Enalaprilat is the active metabolite of enalapril (Item No. 16041), an ACE inhibitor with roles in the management of hypertension, congestive heart failure, myocardial infarction, and diabetic nephropathies.{25199}. Enalaprilat is esterified with ethanol to produce enalapril in order to enable oral activity and subsequently metabolized in vivo to the active form by various esterases. Enalaprilat is reported to inhibit ACE activity with an IC50 value of 5.8 nM in vitro.{26177}  

 

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Description

The active metabolite of the ACE inhibitor, enalapril; inhibits ACE activity with an IC50 value of 5.8 nM in vitro

Formal name: N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-L-proline, dihydrate

Synonyms: 

Molecular weight: 384.4

CAS: 84680-54-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Acetylcholine Turnover||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cardiovascular System|Cardiovascular Diseases|Heart Failure||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Cardiovascular System|Kidney & Renal Disease|Diabetic Nephropathy

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