An ACE inhibitor (IC50 = 1.2 nM in porcine plasma); inhibits angiotensin I-induced pressor responses in rats and dogs from 0.05-1 mg/kg; reduces heart rate

Enalapril (maleate) – 500 mg

Brand:
Cayman
CAS:
76095-16-4
Storage:
-20
UN-No:
Non-Hazardous - /

Enalapril is an inhibitor of angiotensin-converting enzyme (ACE; IC50 = 1.2 nM in porcine plasma).{43103} In vivo, enalapril (0.05-1 mg/kg, p.o.) inhibits pressor responses induced by angiotensin I (Item No. 24737) in rats and dogs in a dose-dependent manner. Enalapril reduces heart rate, systolic and diastolic blood pressures, and heart weight/body weight ratio in salt-sensitive and -resistant Dahl rats fed a high-salt or low-salt diet.{43104} Formulations containing enalapril have been used for the treatment of hypertension, congestive heart failure, myocardial infarction, and diabetic nephropathies.{25199}  

 

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Description

An ACE inhibitor (IC50 = 1.2 nM in porcine plasma); inhibits angiotensin I-induced pressor responses in rats and dogs from 0.05-1 mg/kg; reduces heart rate, systolic and diastolic blood pressures, and heart weight/body weight ratio in salt-sensitive and -resistant Dahl rats fed a high-salt or low-salt diet

Formal name: N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-L-proline, 2Z-butenedioate

Synonyms: 

Molecular weight: 492.5

CAS: 76095-16-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Angiotensin-converting Enzyme||Research Area|Cardiovascular System|Cardiovascular Diseases|Heart Failure||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Cardiovascular System|Kidney & Renal Disease||Research Area|Cardiovascular System|Vasculature|Vasodilation

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