A potential impurity found in commercial emtricitabine preparations

Emtricitabine S-oxide – 1 mg

Brand:
Cayman
CAS:
152128-77-3
Storage:
-20
UN-No:
Non-Hazardous - /

Emtricitabine S-oxide is a potential impurity found in commercial preparations of emtricitabine.{47152} Emtricitabine (Item No. 16879) is a nucleoside analog and an inhibitor of HIV-1 and hepatitis B reverse transcriptase with antiviral activity.{53352} It inhibits replication of HIV-1 (EC50s = 10-20 nM) and hepatitis B (EC50s = 10-40 nM) in various cell lines.{27859} Emtricitabine inhibits duck hepatitis B viral DNA synthesis when administered pre- and post-viral inoculation in primary duck hepatocytes.{53353} In vivo, emtricitabine (3-30 mg/kg) reduces viremia and hepatic woodchuck hepatitis virus (WHV) replication in a dose-dependent manner in a woodchuck model of chronic WHV infection.{53354} Formulations containing emtricitabine have been used in the treatment of HIV infection.  

 

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SKU: 26654 - 1 mg Category:

Description

A potential impurity found in commercial emtricitabine preparations,,

Formal name: 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-3-oxido-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone

Synonyms: 

Molecular weight: 263.2

CAS: 152128-77-3

Purity: ≥98% (mixture of diastereomers)

Formulation: A solid

Product Type|Biochemicals|Antivirals|Nucleoside Reverse Transcriptase Inhibitors (NRTIs)||Product Type|Biochemicals|Nucleotides/Nucleosides||Product Type|Biochemicals|Pharmaceutical Impurities||Product Type|Biochemicals|Small Molecule Inhibitors|Reverse Transcriptases||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Hepatitis||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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