An antiviral nucleoside analog; an inhibitor of HIV-1 and hepatitis B reverse transcriptase; inhibits replication of HIV-1 (EC50s = 10-20 nM) and hepatitis B (EC50s = 10-40 nM) in various cell lines; inhibits duck hepatitis B viral DNA synthesis when administered pre- and post-viral inoculation in primary duck hepatocytes; reduces viremia and hepatic WHV replication in a dose-dependent manner in a woodchuck model of chronic WHV infection

Emtricitabine – 250 mg

Brand:
Cayman
CAS:
143491-57-0
Storage:
-20
UN-No:
Non-Hazardous - /

Emtricitabine is a nucleoside analog and an inhibitor of HIV-1 and hepatitis B reverse transcriptase with antiviral activity.{53352} It inhibits replication of HIV-1 (EC50s = 10-20 nM) and hepatitis B (EC50s = 10-40 nM) in various cell lines.{27859} Emtricitabine inhibits duck hepatitis B viral DNA synthesis when administered pre- and post-viral inoculation in primary duck hepatocytes.{53353} In vivo, emtricitabine (3-30 mg/kg) reduces viremia and hepatic woodchuck hepatitis virus (WHV) replication in a dose-dependent manner in a woodchuck model of chronic WHV infection.{53354} Formulations containing emtricitabine have been used in the treatment of HIV infection.  

 

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Description

An antiviral nucleoside analog; an inhibitor of HIV-1 and hepatitis B reverse transcriptase; inhibits replication of HIV-1 (EC50s = 10-20 nM) and hepatitis B (EC50s = 10-40 nM) in various cell lines; inhibits duck hepatitis B viral DNA synthesis when administered pre- and post-viral inoculation in primary duck hepatocytes; reduces viremia and hepatic WHV replication in a dose-dependent manner in a woodchuck model of chronic WHV infection

Formal name: 4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone

Synonyms:  BW 1592|BW 524W91|FTC

Molecular weight: 247.2

CAS: 143491-57-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Nucleoside Reverse Transcriptase Inhibitors (NRTIs)||Product Type|Biochemicals|Nucleotides/Nucleosides||Product Type|Biochemicals|Small Molecule Inhibitors|Reverse Transcriptases||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Hepatitis||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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