Description
An alkaloid with diverse biological activities; active against several strains of E. histolytica amoebae (IC50s = 0.73-10.22 μg/ml); inhibits NF-κB signaling induced by TNF-α or IL-1β (IC50s = 2 and 4.2 μM, respectively, in a cell-based β-lactamase reporter assay); increases caspase-3/7 activity in ME180 cells (EC50 = 1.1 μM); cytotoxic to HeLa cells; reduces the infectious virus yield and viral RNA copy numbers in the culture supernatant of Vero E6 cells infected with SARS-CoV-2 (EC50s = 0.46 and 0.5 μM, respectively); induces emesis in ferrets at 5 mg/kg, an effect that can be prevented by ondansetron
Formal name: (2S,3R,11bS)-3-ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolinyl]methyl]-2H-benzo[a]quinolizine, dihydrochloride, hydrate
Synonyms:
Molecular weight: 553.6
CAS: 7083-71-8
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Antiparasitics|Antiamoebics||Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Pulmonary Diseases|COVID-19||Research Area|Infectious Disease|Parasitic Diseases||Research Area|Infectious Disease|Viral Diseases|Coronaviruses||Research Area|Neuroscience
