Description
A mycotoxin; active against C. albicans and C. neoformans, as well as E. coli, S. aureus, and MRSA (IC50s = 3.94, 0.6, 2.21, 4.55, and 2.21 µg/ml, respectively); a CCR2 antagonist (IC50 = 5.4 µM in a radioligand binding assay using isolated human monocytes); induces apoptosis in HL-60 cells at 0.1 µg/ml; induces heart, thymus, and liver tissue necrosis in mice at 18-30 mg/kg
Formal name: (1R,2R,6aS,20S,21R,22bS)-6a,22b-dihydro-2,16,20-trihydroxy-12-methoxy-25-methyl-2H,8H,20H,22H-1,21-epidithio-21,1-(iminomethano)-9,13:15,19-dimetheno-4,7,14-trioxa-22a-azacyclononadec[cd]azulene-8,22,26-trione
Synonyms:
Molecular weight: 598.6
CAS: 97816-62-1
Purity: ≥95%
Formulation: A solid
