Description
An inhibitor of SGK1; inhibits SGK1 by 85% at 1 µM; >27-fold selective for SGK1 over a panel of 11 kinases, but does inhibit SGK2, SGK3, PRK2, and MSK1 by >50% at 1 µM; inhibits phosphorylation of the SGK1 target NDRG1 in HeLa cells (IC50 = 3.35 µM); increases radiation-induced apoptosis of Caco-2 colon carcinoma cells at 50 µM; dietary administration reduces the number of tumors in a mouse model of chemical carcinogenesis; prevents fructose and saline consumption-induced increases in systolic blood pressure in mice; decreases body weight, fasting blood glucose and HbA1c levels, and food intake in db/db diabetic mice; reduces angiotensin II-induced collagen deposition and cardiac fibrosis in mice
Formal name: 3,5-difluoro-α-hydroxy-benzeneacetic acid, 2-(2-ethyl-4-hydroxy-3-methylbenzoyl)hydrazide
Synonyms:
Molecular weight: 364.3
CAS: 1181770-72-8
Purity: ≥98%
Formulation: A crystalline solid
