An insecticide; a semi-synthetic derivative of avermectin B1a; binds to GABAA receptors (Ki = 17.6 nM in rat brain membranes)

Emamectin B1a – 1 mg

Brand:
Cayman
CAS:
121124-29-6
Storage:
-20
UN-No:
Non-Hazardous - /

Emamectin B1a is a semi-synthetic derivative of avermectin B1a (Item No. 22000).{35148} It binds to GABAA receptors (Ki = 17.6 nM in rat brain membranes), including those containing β1, β2, or β3 subunits (IC50s = 57, 210, and 49.8 nM for α1β1γ2, α1β2γ2, and α1β3γ2 subunits, respectively), and potentiates the GABA response.{35146} Emamectin B1a also binds to and inhibits glycine receptors (IC50 = 218 nM in rat spinal cord). Emamectin B1a induces mortality in 90% of S. exigua larvae in a diet incorporation assay at a dose of 1.067 ng/ml, which is approximately 1,500-fold more toxic than avermectin B1. It is effective against neonate S. eridania larvae in a foliage spray bioassay and when applied topically.  

 

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SKU: 24060 - 1 mg Category:

Description

An insecticide; a semi-synthetic derivative of avermectin B1a; binds to GABAA receptors (Ki = 17.6 nM in rat brain membranes), including those containing β1, β2, or β3 subunits (IC50s = 57, 210, and 49.8 nM for α1β1γ2, α1β2γ2, and α1β3γ2 subunits, respectively); potentiates the GABA response; binds to and inhibits glycine receptors (IC50 = 218 nM in rat spinal cord); induces mortality in 90% of S. exigua larvae in a diet incorporation assay at a dose of 1.067 ng/ml

Formal name: (4”R)-5-O-demethyl-4”-deoxy-4”-(methylamino)-avermectin A1a

Synonyms:  L-656,748

Molecular weight: 886.1

CAS: 121124-29-6

Purity: ≥99%

Formulation: A solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Pesticides|Insecticides||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience||Research Area|Toxicology|Environmental|Agriculture

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