A motilin receptor agonist (IC50 = 6.17 nM for binding to rabbit gastric antral smooth muscle homogenates); binds to human smooth muscle homogenates (Kd = 7.8 nM); induces contraction of isolated rabbit intestine (EC50 = 5.5 nM); increases antral motility and enhances gastric emptying in canine models of gastroparesis at 0.03 mg/kg intraduodenally following a semi-solid meal

EM574 – 500 µg

Brand:
Cayman
CAS:
110480-13-2
Storage:
-20
UN-No:
Non-Hazardous - /

EM574 is a motilin receptor agonist with an IC50 value of 6.17 nM for binding to rabbit gastric antral smooth muscle homogenates in a radioligand binding assay.{45198} It also binds to human smooth muscle homogenates in a radioligand binding assay (Kd = 7.8 nM).{45199} EM574 induces contraction of isolated rabbit, but not rat or guinea pig, intestine (EC50 = 5.5 nM).{45198} It increases antral motility and enhances gastric emptying in canine models of gastroparesis when administered intraduodenally at a dose of 0.03 mg/kg following a semi-solid meal.{45200}  

 

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SKU: 27752 - 500 µg Category:

Description

A motilin receptor agonist (IC50 = 6.17 nM for binding to rabbit gastric antral smooth muscle homogenates); binds to human smooth muscle homogenates (Kd = 7.8 nM); induces contraction of isolated rabbit intestine (EC50 = 5.5 nM); increases antral motility and enhances gastric emptying in canine models of gastroparesis at 0.03 mg/kg intraduodenally following a semi-solid meal

Formal name: 8,9-didehydro-N-demethyl-9-deoxo-6-deoxy-6,9-epoxy-N-(1-methylethyl)-erythromycin

Synonyms:  Idremcinal

Molecular weight: 744

CAS: 110480-13-2

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists

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