A quinolone antibiotic that inhibits HIV-1 integrase (IC50 = 7.2 nM); has antiviral activity against laboratory strains and clinical isolates of HIV-1 in MAGI cells (EC50s = 0.1-1.26 nM) and HIV-2 in PBMCs (EC50s = 0.3-0.9)

Elvitegravir – 5 mg

Brand:
Cayman
CAS:
697761-98-1
Storage:
-20
UN-No:
Non-Hazardous - /

Elvitegravir is a quinolone antibiotic that inhibits HIV-1 integrase (IC50 = 7.2 nM).{29011} It has antiviral activity against laboratory strains and clinical isolates of HIV-1 in MAGI cells (EC50s = 0.1-1.26 nM) and HIV-2 in peripheral blood mononuclear cells (PBMCs; EC50s = 0.3-0.9).{20011,42943} Formulations containing elvitegravir have been used in the treatment of HIV infections.  

 

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Description

A quinolone antibiotic that inhibits HIV-1 integrase (IC50 = 7.2 nM); has antiviral activity against laboratory strains and clinical isolates of HIV-1 in MAGI cells (EC50s = 0.1-1.26 nM) and HIV-2 in PBMCs (EC50s = 0.3-0.9)

Formal name: 6-[(3-chloro-2-fluorophenyl)methyl]-1,4-dihydro-1-[(1S)-1-(hydroxymethyl)-2-methylpropyl]-7-methoxy-4-oxo-3-quinolinecarboxylic acid

Synonyms:  GS-9137|JTK-303

Molecular weight: 447.9

CAS: 697761-98-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Quinolones & Fluoroquinolones||Product Type|Biochemicals|Antivirals||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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