An inhibitor of tubulin polymerization (IC50 = 10 μM); binds to tubulin at the colchicine binding site; induces microtubule depolymerization in A-10 cells (EC50 = 21 nM); inhibits growth in a cancer cell line panel (IC50s = 9-43 nM) via formation of multiple spindles and induction of mitotic arrest; reduces tumor size in an MDA-MB-231 breast cancer mouse xenograft model in a dose-dependent manner; inhibits HIF-1α in RCC4 cells in a concentration-dependent manner

ELR510444 – 5 mg

Brand:
Cayman
CAS:
1233948-35-0
Storage:
-20
UN-No:
Non-Hazardous - /

ELR510444 is an inhibitor of tubulin polymerization (IC50 = 10 μM) that binds to tubulin at the colchicine (Item No. 9000760) binding site.{38488} It induces microtubule depolymerization in A-10 cells (EC50 = 21 nM). ELR510444 inhibits growth in a cancer cell line panel (IC50s = 9-43 nM) via formation of multiple spindles and induction of mitotic arrest. Oral administration of ELR510444 (3-6 mg/kg) reduces tumor size in an MDA-MB-231 breast cancer mouse xenograft model in a dose-dependent manner. ELR510444 also inhibits hypoxia-inducible factor 1α (HIF-1α) in RCC4 cells in a concentration-dependent manner.{38487}  

 

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Description

An inhibitor of tubulin polymerization (IC50 = 10 μM); binds to tubulin at the colchicine binding site; induces microtubule depolymerization in A-10 cells (EC50 = 21 nM); inhibits growth in a cancer cell line panel (IC50s = 9-43 nM) via formation of multiple spindles and induction of mitotic arrest; reduces tumor size in an MDA-MB-231 breast cancer mouse xenograft model in a dose-dependent manner; inhibits HIF-1α in RCC4 cells in a concentration-dependent manner,

Formal name: N-[5-(5-cyano-2-thienyl)-2-methylphenyl]-4-methyl-benzenesulfonamide

Synonyms: 

Molecular weight: 368.5

CAS: 1233948-35-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Microtubule Dynamics||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer

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