A macrodiolide antibiotic that displays anti-protozoal activity against both Plasmodium and Trypanosoma (IC50s = 370 and 460 ng/ml

Elaiophylin – 1 mg

Brand:
Cayman
CAS:
37318-06-2
Storage:
-20
UN-No:
Non-Hazardous - /

Elaiophylin is a macrodiolide antibiotic that can be isolated from various strains of Streptomyces.{25429,25428} It displays in vitro anti-protozoal activity against both Plasmodium and Trypanosoma (IC50s = 370 and 460 ng/ml, respectively) and cytotoxicity against human fetal lung fibroblast MRC-5 cells (IC50 = 870 ng/ml).{25430} Elaiophylin alone has no activity against Candida, although it enhances the anti-fungal activity of rapamycin (Item No. 13346).{25428} Elaiophylin also forms stable, long-lasting ion channels in bilayer membranes that are selective for cations.{25431}  

 

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Description

A macrodiolide antibiotic that displays anti-protozoal activity against both Plasmodium and Trypanosoma (IC50s = 370 and 460 ng/ml, respectively) and cytotoxicity against MRC-5 cells (IC50 = 870 ng/ml); enhances the anti-fungal activity of rapamycin

Formal name:

Synonyms:  Azalomycin-B|Gopalamicin|Salbomycin

Molecular weight: 1,025.30

CAS: 37318-06-2

Purity: ≥95%

Formulation: A neat solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases

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