A dual inhibitor of adenosine deaminase (IC50 = 1.2 μM in human red blood cells) and PDE2 (IC50s = 0.8 and 2 μM from human and pig myocardium

EHNA (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
58337-38-5
Storage:
-20
UN-No:
Non-Hazardous - /

EHNA is a reversible adenosine deaminase inhibitor (IC50 = 1.2 μM in human red blood cells) that also selectively inhibits the cGMP-specific phosphodiesterase (PDE2) (IC50s = 0.8 and 2 μM from human and porcine myocardium, respectively, 3.5 μM in rat hepatocyte, and 5.5 μM in human platelet).{20010,20014} Comparatively, EHNA is much less potent at inhibiting PDE1, PDE3, or PDE4 (IC50s > 100 μM).{20010} EHNA has been used to evaluate cardioprotective and neuroprotective effects during ischemia, to study the role of cAMP/cGMP signaling, and to maintain pluripotency/prevent differentiation of human embryonic stem cells.{20013,20012,20011}  

 

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Description

A dual inhibitor of adenosine deaminase (IC50 = 1.2 μM in human red blood cells) and PDE2 (IC50s = 0.8 and 2 μM from human and pig myocardium, respectively, 3.5 μM in rat hepatocyte, and 5.5 μM in human platelet)

Formal name: (αR,βS)-rel-6-amino-β-hexyl-α-methyl-9H-purine-9-ethanol, monohydrochloride

Synonyms:  erythro-9-(2-Hydroxy-3-nonyl)adenine|NSC 263164

Molecular weight: 313.8

CAS: 58337-38-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Cell Biology|Cell Signaling|cAMP Signaling||Research Area|Cell Biology|Stem Cell Research|Differentiation

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