EGCG Octaacetate – 50 mg

Brand:
Cayman
CAS:
148707-39-5
Storage:
-20
UN-No:
Non-Hazardous - /

EGCG octaacetate is a prodrug form of (–)-epigallocatechin gallate (EGCG; Item No. 70935).{59063} It is cleaved by intracellular esterases to form EGCG. EGCG octaacetate (50 µM) reduces proteasome activity in MDA-MB-231 breast cancer cells extracts.{59064} It induces apoptosis in, and inhibits proliferation of, MDA-MB-231 cells when used at the same concentration. Dietary administration of EGCG octaacetate (0.085%) decreases colonic IL-6, IL-1β, and TNF-α levels, as well as reduces colonic shortening, tissue damage, and inflammatory cell infiltration in a mouse model of colitis induced by dextran sulfate sodium (DSS; Item No. 23250).{59065}  

 

Available on backorder

SKU: 31144 - 50 mg Category:

Description

A prodrug form of EGCG; cleaved by intracellular esterases to form EGCG; reduces proteasome activity in MDA-MB-231 breast cancer cells extracts at 50 µM; induces apoptosis in, and inhibits proliferation of, MDA-MB-231 cells at 50 µM; decreases colonic IL-6, IL-1β, and TNF-α levels, as well as reduces colonic shortening, tissue damage, and inflammatory cell infiltration in a DSS-induced mouse model of colitis at 0.085%


Formal name: 3,4,5-tris(acetyloxy)-benzoic acid, (2R,3R)-5,7-bis(acetyloxy)-3,4-dihydro-2-[3,4,5-tris(acetyloxy)phenyl]-2H-1-benzopyran-3-yl ester

Synonyms: 

Molecular weight: 794.7

CAS: 148707-39-5

Purity: ≥98%

Formulation: A crystalline solid