A potent inhibitor of Eg5

Eg5-I – 5 mg

Brand:
Cayman
CAS:
1338701-15-7
Storage:
-20
UN-No:
Non-Hazardous - /

The kinesin-like spindle protein Eg5, also known as KSP and Kif11, is a motor protein that is essential for establishing a bipolar spindle during mitosis.{22151} Eg5-I is a potent inhibitor of Eg5, both in vitro and in cells (IC50s = 127 and 190 nM, respectively).{26966} It is an analog of S-trityl-L-cysteine (STLC), but is more potent and has better solubility than STLC. Eg5-I blocks bipolar spindle formation and inhibits the growth of cancer cells, with an average GI50 value of 360 nM against a broad panel of tumor cells (GI50 range = 10 nM to 3 µM).{26966} It ranges from 140- to 1200-fold more potent against cancer cells than monastrol (Item No. 15044), which also acts by inhibiting Eg5.{22151,26966}  

 

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Description

A potent inhibitor of Eg5, both in vitro and in cells (IC50s = 127 and 190 nM, respectively); blocks bipolar spindle formation and inhibits the growth of cancer cells, with an average GI50 value of 360 nM against a broad panel of tumor cells

Formal name: (2R)-2-amino-3-[[(4-methoxyphenyl)diphenylmethyl]thio]-1-propanol

Synonyms: 

Molecular weight: 379.5

CAS: 1338701-15-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Cycle|G2/M

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