A triazole antifungal agent; inhibits the growth of T. rubrum and T. mentagrophytes clinical isolates (MICs of ≤2 to 60 ng/ml) and of C. albicans clinical isolates (MICs of ≤0.5 to >250 ng/ml); inhibits sterol 14α-demethylase and arrests ergosterol biosynthesis at the fungal membrane; inhibits ergosterol biosynthesis in T. mentagrophytes and C. albicans with (IC50s = 7.0 and 0.40 ng/ml

Efinaconazole – 100 mg

Brand:
Cayman
CAS:
164650-44-6
Storage:
-20
UN-No:
Non-Hazardous - /

Efinaconazole is a broad-spectrum triazole antifungal agent with activity against Acremonium, Aspergillus, Candida, Cryptococcus, Epidermophyton, Fusarium, Microsporum, Paecilomyces, Pseudallescheria, Scopulariopsis, Trichophyton, and Trichosporon.{41490} It inhibits the growth of T. rubrum and T. mentagrophytes clinical isolates with MIC values ranging from ≤2.0 to 60 ng/ml and of C. albicans isolates with MIC values ranging from ≤0.5 to >250 ng/ml. Efinaconazole inhibits sterol 14α-demethylase, which arrests ergosterol (Item No. 19850) biosynthesis at the fungal membrane.{41491} It inhibits ergosterol biosynthesis in T. mentagrophytes and C. albicans with IC50 values of 7.0 and 0.40 ng/ml, respectfully. Topical formulations containing efinaconazole have been used for the treatment of onychomycosis.  

 

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SKU: 23839 - 100 mg Category:

Description

A triazole antifungal agent; inhibits the growth of T. rubrum and T. mentagrophytes clinical isolates (MICs of ≤2 to 60 ng/ml) and of C. albicans clinical isolates (MICs of ≤0.5 to >250 ng/ml); inhibits sterol 14α-demethylase and arrests ergosterol biosynthesis at the fungal membrane; inhibits ergosterol biosynthesis in T. mentagrophytes and C. albicans with (IC50s = 7.0 and 0.40 ng/ml, respectfully)

Formal name: αR-(2,4-difluorophenyl)-βR-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol

Synonyms:  KP-103

Molecular weight: 348.4

CAS: 164650-44-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antifungals|Triazoles||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Endocrinology & Metabolism|Hormones & Receptors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases|Aspergillosis||Research Area|Infectious Disease|Fungal Diseases|Candidiasis

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