A phenylethanoid glycoside; scavenges DPPH radicals (EC50 = 6.6 µM in a cell-free assay); inhibits hydrogen peroxide-induced production of ROS in a cell-free assay at 10 µg/ml; reduces increases in plasma ALT

Echinacoside – 10 mg

Brand:
Cayman
CAS:
82854-37-3
Storage:
-20
UN-No:
Non-Hazardous - /

Echinacoside is a phenylethanoid glycoside that has been found in Echinacea and has diverse biological activities.{53590,53591,53592,53593} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals (EC50 = 6.6 µM in a cell-free assay).{53590} Echinacoside (10 µg/ml) inhibits hydrogen peroxide-induced production of reactive oxygen species (ROS) and apoptosis in PC12 cells.{53591} It reduces increases in plasma alanine aminotransferase (ALT), TNF-α, IL-1β, IL-16, and IL-10 levels and hepatocyte apoptosis induced by LPS/D-galactosamine in a mouse model of acute liver injury when administered at a dose of 60 mg/kg.{53592} Echinacoside (20 mg/kg per day for 15 days) prevents loss of dopaminergic neurons in the substantia nigra pars compacta and decreases in striatal dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) levels in a mouse model of MPTP-induced Parkinson’s disease.{53593} It also improves motor performance in the rotarod test in the same model.  

 

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Description

A phenylethanoid glycoside; scavenges DPPH radicals (EC50 = 6.6 µM in a cell-free assay); inhibits hydrogen peroxide-induced production of ROS in a cell-free assay at 10 µg/ml; reduces increases in plasma ALT, TNF-α, IL-1β, IL-16, and IL-10 levels and hepatocyte apoptosis induced by LPS/D-galactosamine in a mouse model of acute liver injury at 60 mg/kg; prevents loss of dopaminergic neurons in the substantia nigra pars compacta and decreases in striatal dopamine and DOPAC levels in a mouse model of MPTP-induced Parkinson’s disease; improves motor performance in the rotarod test in the same model,,

Formal name: 2-(3,4-dihydroxyphenyl)ethyl O-6-deoxy-α-L-mannopyranosyl-(1→3)-O-[β-D-glucopyranosyl-(1→6)]-β-D-glucopyranoside, 4-[3-(3,4-dihydroxyphenyl)-2-propenoate]

Synonyms:  trans-Acteoside|trans-Verbascoside|Kusaginin|NSC 603831

Molecular weight: 786.7

CAS: 82854-37-3

Purity: ≥95%

Formulation: A crystalline solid

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