An antiulcerative and gastroprotective agent; reduces the viability of H. pylori grown under urea-supplemented acidic conditions in a concentration-dependent manner; inhibits H. pylori urease activity in a pH-dependent manner (IC50s = 2.1-2.6 and >16 mg/ml at pH values of 5 and 8

Ecabet (sodium salt) – 5 mg

Brand:
Cayman
CAS:
86408-72-2
Storage:
-20
UN-No:
Non-Hazardous - /

Ecabet is an antiulcerative and gastroprotective agent.{50298,50299,50306,50307} It reduces the viability of H. pylori grown under urea-supplemented acidic conditions in a concentration-dependent manner.{50298} Ecabet inhibits H. pylori urease activity in a pH-dependent manner (IC50s = 2.1-2.6 and >16 mg/ml at pH values of 5 and 8, respectively). It inhibits adhesion of H. pylori to MKN-28 cells when used at concentrations of 1 and 2 mg/ml.{50299} In vivo, ecabet (25 and 100 mg/kg, p.o.) increases levels of prostaglandin E2 (PGE2; Item No. 14010) in rat gastric mucosa.{50306} It inhibits formation of hemorrhagic lesions in esophageal mucosa and reduces gastric juice pepsin activity in a rat model of reflux induced by fore-stomach and pyloric ligation when administered at a dose of 30 mg/kg.{50307}  

 

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Description

An antiulcerative and gastroprotective agent; reduces the viability of H. pylori grown under urea-supplemented acidic conditions in a concentration-dependent manner; inhibits H. pylori urease activity in a pH-dependent manner (IC50s = 2.1-2.6 and >16 mg/ml at pH values of 5 and 8, respectively); inhibits adhesion of H. pylori to MKN-28 cells at 1 and 2 mg/ml; increases levels of PGE2 in rat gastric mucosa at 25 and 100 mg/kg, p.o. in vivo; inhibits formation of hemorrhagic lesions in esophageal mucosa and reduces gastric juice pepsin activity in a rat model of reflux induced by fore-stomach and pyloric ligation at 30 mg/kg

Formal name: (1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-6-sulfo-1-phenanthrenecarboxylic acid, monosodium salt

Synonyms:  ,TA-2711

Molecular weight: 402.5

CAS: 86408-72-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation|Gastric Disease|Peptic Ulcers||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Infectious Disease|Bacterial Diseases

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