A β-lactone that stimulates host defense in immune cells by inhibiting cell surface esterases

Ebelactone A – 500 µg

Brand:
Cayman
CAS:
76808-16-7
Storage:
-20
UN-No:
Non-Hazardous - /

Ebelactone A is a β-lactone enzyme inhibitor that was first isolated from a cultured strain of soil actinomycetes.{30989} It can inhibit esterases, lipases, and N-formylmethionine aminopeptidases (IC50s = 0.056, 0.003, and 0.08 µg/ml, respectively) found on cell surfaces, which has been shown to stimulate host defense in immune cells.{30988} Ebelactone A is also reported to inhibit cutinases produced by fungal pathogens, thus demonstrating a plant-protective function.{30987}  

 

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Description

A β-lactone that stimulates host defense in immune cells by inhibiting cell surface esterases, lipases, and N-formylmethionine aminopeptidases with IC50 values of 0.056, 0.003, and 0.08 µg/ml, respectively; also inhibits cutinases produced by fungal pathogens, thus demonstrating a plant-protective function

Formal name: (3S,4S)-4-[(1S,3E,5R,7S,8R,9R)-8-hydroxy-1,3,5,7,9-pentamethyl-6-oxo-3-undecen-1-yl]-3-methyl-2-oxetanone

Synonyms:  (−)-Ebelactone A|NSC 335650

Molecular weight: 338.5

CAS: 76808-16-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Immunology & Inflammation||Research Area|Plant Biology|Phytoprotectants

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