A synthetic vitamin D analog that inhibits cell proliferation and differentiation with reduced calcemic activity compared to that of calcitriol; promotes tumor regression in vitro by inducing apoptosis

EB 1089 – 1 mg

Brand:
Cayman
CAS:
134404-52-7
Storage:
-20
UN-No:
Non-Hazardous - /

EB 1089 is a synthetic vitamin D analog that is 50-200 times more potent than calcitriol (Item No. 71820) at inhibiting cell proliferation and differentiation, yet displays reduced calcemic activity compared to that of calcitriol.{33493} It has been shown to promote tumor regression in vitro by inducing apoptosis.{33494}  

 

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Description

A synthetic vitamin D analog that inhibits cell proliferation and differentiation with reduced calcemic activity compared to that of calcitriol; promotes tumor regression in vitro by inducing apoptosis

Formal name: (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4E)-6-ethyl-6-hydroxy-1-methyl-2,4-octadien-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-cyclohexanediol

Synonyms:  Seocalcitol

Molecular weight: 454.7

CAS: 134404-52-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Death|Apoptosis

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