An angiogenesis inhibitor with anticancer activity; inhibits bFGF- and VEGF-stimulated HUVEC proliferation (IC50s = 0.1 and 0.081 μg/ml

E7820 – 5 mg

Brand:
Cayman
CAS:
289483-69-8
Storage:
-20
UN-No:
Non-Hazardous - /

E7820 is a sulfonamide derivative and an angiogenesis inhibitor that inhibits bFGF- and VEGF-stimulated human umbilical vein endothelial cell (HUVEC) proliferation (IC50s = 0.1 and 0.081 μg/ml, respectively).{39954} It inhibits bFGF- and VEGF-stimulated tube formation of HUVECs in a concentration-dependent manner (IC50s = 0.2 and 0.24 μg/ml, respectively). E7820 selectively decreases the surface expression and mRNA levels of integrin α2 over CD31 and VE-cadherin in HUVECs. In vivo, E7820 (200 and 400 mg/kg) reduces tumor growth and inhibits angiogenesis in a WiDr colorectal cancer mouse xenograft model. It also reduces tumor weight in a panel of seven human colon, breast, pancreas, and kidney cancer mouse xenograft models, completely inhibits tumor growth in KP-1 pancreatic and LoVo colon cancer mouse xenograft models, and inhibits tumor growth in KP-1 and COLO 320DM mouse orthotopic transplantation models.{39955}  

 

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SKU: 25502 - 5 mg Category:

Description

An angiogenesis inhibitor with anticancer activity; inhibits bFGF- and VEGF-stimulated HUVEC proliferation (IC50s = 0.1 and 0.081 μg/ml, respectively); inhibits bFGF- and VEGF-stimulated tube formation of HUVECs (IC50s = 0.2 and 0.24 μg/ml, respectively); selectively decreases the surface expression and mRNA levels of integrin α2 over CD31 and VE-cadherin in HUVECs; reduces tumor growth and inhibits angiogenesis in a WiDr colorectal cancer mouse xenograft model at 200 and 400 mg/kg; reduces tumor weight in a panel of seven human colon, breast, pancreas, and kidney cancer mouse xenograft models; completely inhibits tumor growth in KP-1 pancreatic and LoVo colon cancer mouse xenograft models; inhibits tumor growth in KP-1 and COLO 320DM mouse orthotopic transplantation models,

Formal name: 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)-benzenesulfonamide

Synonyms: 

Molecular weight: 336.4

CAS: 289483-69-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Angiogenesis

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