The E isomer of the pyrophosphonate form of HDMAPP; potently stimulates the synthesis of TNF-α by γδ-T lymphocytes with an IC50 valueof 0.91 nM; also significantly increases the number of circulating γδ-T cells in vivo; stable both in solution and in vascular circulation.{16651}

(E)-C-HDMAPP (ammonium salt) – 1 mg

Brand:
Cayman
CAS:
933030-60-5
Storage:
-20
UN-No:
Non-Hazardous - /

Synthetic and natural alkyl phosphates, also known as phosphoantigens, stimulate the proliferation of γδ-T lymphocytes.{17387} Isopentenyl pyrophosphate, and related derivatives including (E)-hydroxy-dimethyl-allyl pyrophosphate ((E)-HDMAPP), are particularly effective activators of γδ-T cells.{17389}{17388} (E)-C-HDMAPP is the pyrophosphonate form of (E)-HDMAPP. The pyrophosphonate moiety in (E)-C-HDMAPP is much less susceptible to chemical or enzymatic hydrolysis than its pyrophosphate counterpart. As a result, (E)-C-HDMAPP is much more stable in solution and in vascular circulation.{16651} (E)-C-HDMAPP possesses comparable activity to (E)-HDMAPP, which is the most potent of the isoprenoid phosphoantigens. (E)-C-HDMAPP stimulates the synthesis of tumor necrosis factor (TNF-α) by γδ-T lymphocytes with an IC50 value of 0.91 nM.{16651} (E)-C-HDMAPP also significantly increases the number of circulating γδ-T cells in vivo, in cynomolgus monkeys.{16651}  

 

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Description

The E isomer of the pyrophosphonate form of HDMAPP; potently stimulates the synthesis of TNF-α by γδ-T lymphocytes with an IC50 valueof 0.91 nM; also significantly increases the number of circulating γδ-T cells in vivo; stable both in solution and in vascular circulation.{16651}

Formal name: P’-[(3E)-5-hydroxy-4-methyl-3-penten-1-yl]-isohypophosphoric acid, triammonium salt

Synonyms:  (​E)-5-hydroxy-4-methylpent-3-enyl pyrophosphate

Molecular weight: 311.2

CAS: 933030-60-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Immunology & Inflammation|Adaptive Immunity

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