A pyrimidine base; is an inactive metabolite of the antiviral agents sorivudine and BVDU that may be regenerated to BVDU in vivo; irreversibly inactivates DPD in an NADPH-dependent manner; enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-FU in a P388 murine leukemia model at 200 µmol/kg

(E)-5-(2-Bromovinyl)uracil – 250 mg

Brand:
Cayman
CAS:
69304-49-0
Storage:
-20
UN-No:
Non-Hazardous - /

(E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2′-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo.{42576,42577,42575} BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner.{42576,42578} It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil (5-FU; Item No. 14416) in a P388 murine leukemia model when administered at a dose of 200 µmol/kg, increasing survival time.{42578}  

 

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Description

A pyrimidine base; is an inactive metabolite of the antiviral agents sorivudine and BVDU that may be regenerated to BVDU in vivo; irreversibly inactivates DPD in an NADPH-dependent manner; enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-FU in a P388 murine leukemia model at 200 µmol/kg, increasing survival time

Formal name: 5-[(1E)-2-bromoethenyl]-2,4(1H,3H)-pyrimidinedione

Synonyms:  BVU

Molecular weight: 217

CAS: 69304-49-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Synthetic Intermediates & Building Blocks||Research Area|Cancer||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases

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