A sphingolipid degradation product that has been shown to induce cytoskeletal reorganization and eventual apoptosis via a JNK-dependent pathway; reacts readily with deoxyguanosine and DNA to form aldehyde-derived DNA adducts

(E)-2-Hexadecenal – 5 mg

Brand:
Cayman
CAS:
22644-96-8
Storage:
-20
UN-No:
Non-Hazardous - /

Sphingosine-1-phosphate (S1P), a bioactive lipid involved in many signaling processes, is irreversibly degraded by the membrane-bound S1P lyase. (E)-2-Hexadecenal is a sphingolipid degradation product resulting from the action of S1P lyase. It can be further oxidized to (2E)-hexadecenoic acid by long-chain fatty aldehyde dehydrogenase prior to activation via coupling to coenzyme A. (E)-2-Hexadecenal has been shown to induce cytoskeletal reorganization that results in cell rounding, detachment, activation of downstream JNK targets, and eventual apoptosis in various cell types.{28538} It reacts readily with deoxyguanosine and DNA to form aldehyde-derived DNA adducts.{28539}  

 

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Description

A sphingolipid degradation product that has been shown to induce cytoskeletal reorganization and eventual apoptosis via a JNK-dependent pathway; reacts readily with deoxyguanosine and DNA to form aldehyde-derived DNA adducts

Formal name: (2E)-2-hexadecenal

Synonyms:  trans-2-Hexadecenal

Molecular weight: 238.4

CAS: 22644-96-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Fatty Acids||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cytoskeleton & Motor Proteins||Research Area|Lipid Biochemistry|Sphingolipids

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