A stilbene derivative with antioxidant and anticancer activities; stimulates proliferation of hydrogen peroxide-damaged ECV-304 cells (EC50 = 24.9 nM); reduces hydrogen peroxide-induced release of LDH in and increases viability of HUVECs; reverses hydrogen peroxide-induced release of MDA and decreases in SOD and GSH-Px activities and increases cNOS activity and NO production in HUVECs; induces cell death of A549 NSCLC cells in an IRE1α-dependent manner

(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine – 5 mg

Brand:
Cayman
CAS:
1000672-89-8
Storage:
-20
UN-No:
Non-Hazardous - /

(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine (CSTMP) is a stilbene derivative with antioxidant and anticancer activities.{43230,43231,43232} It stimulates proliferation of hydrogen peroxide-damaged ECV-304 cells (EC50 = 24.9 nM).{43230} CSTMP reduces hydrogen peroxide-induced release of lactate dehydrogenase (LDH) in and increases viability of human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner via inhibition of apoptosis.{43231} It reverses hydrogen peroxide-induced release of malondialdehyde (MDA) and decreases in superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities as well as increases constitutive nitric oxide synthase (cNOS) activity and nitric oxide (NO) production in HUVECs. CSTMP also induces cell death of A549 non-small cell lung cancer (NSCLC) cells in an IRE1α-dependent manner through induction of IRE1α-TRAF2-ASK1 complex-mediated endoplasmic reticulum (ER) stress and mitochondrial apoptosis.{43232}  

 

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SKU: 9003202 - 5 mg Category:

Description

A stilbene derivative with antioxidant and anticancer activities; stimulates proliferation of hydrogen peroxide-damaged ECV-304 cells (EC50 = 24.9 nM); reduces hydrogen peroxide-induced release of LDH in and increases viability of HUVECs; reverses hydrogen peroxide-induced release of MDA and decreases in SOD and GSH-Px activities and increases cNOS activity and NO production in HUVECs; induces cell death of A549 NSCLC cells in an IRE1α-dependent manner

Formal name: 2-[(1E)-2-(2-chlorophenyl)ethenyl]-3,5,6-trimethyl-pyrazine

Synonyms:  CSTMP

Molecular weight: 258.8

CAS: 1000672-89-8

Purity: ≥98%

Formulation: A crystalline solid

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