A xanthine derivative that acts as an adenosine receptor antagonist and phosphodiesterase inhibitor and exhibits bronchodilator and vasodilator effects; also inhibits mPGES-1 (IC50 = 200 µM) and downregulates ABCG2 drug transporter expression in multidrug resistant tumor cells

Dyphylline – 500 mg

Brand:
Cayman
CAS:
479-18-5
Storage:
-20
UN-No:
Non-Hazardous - /

Dyphylline is a xanthine derivative that acts as an A1 and A2 adenosine receptor antagonist and phosphodiesterase inhibitor and exhibits bronchodilator and vasodilator effects.{29139,29142} It also moderately inhibits microsomal prostaglandin E synthase-1 with an IC50 value of 200 µM and downregulates ABCG2 drug transporter expression in multidrug resistant tumor cells.{29140,29141}  

 

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Description

A xanthine derivative that acts as an adenosine receptor antagonist and phosphodiesterase inhibitor and exhibits bronchodilator and vasodilator effects; also inhibits mPGES-1 (IC50 = 200 µM) and downregulates ABCG2 drug transporter expression in multidrug resistant tumor cells

Formal name: 7-(2,3-dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione

Synonyms:  7-(2,3-Dihydroxypropyl)theophylline|Dilor|Diprophylline|Lufyllin|Neothyllin|NSC 14305|NSC 40844

Molecular weight: 254.2

CAS: 479-18-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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