A topical anesthetic with diverse biological activities; active against various bacteria and fungi (MMCs = 0.006-0.8% v/v); reduces ALDH activity in and viability of HSC-4 cells and enhances sulfasalazine-induced HSC-4 and OSC19 cell death from 25-100 μM; reduces tumor volume in an HSC-2 mouse xenograft model when administered alone or in combination with sulfasalazine at 5 mg/kg; induces cerebral FXN production and decreases time to cross and the number of foot slips in a level beam test in a mouse model of Friedreich's ataxia

Dyclonine (hydrochloride) – 10 g

Brand:
Cayman
CAS:
536-43-6
Storage:
-20
UN-No:
Excepted Quantity - 2811 / 6.1

Dyclonine is a topical anesthetic that also has antimicrobial, anticancer, and neuroprotective properties.{52157,52158,52159} It is active against S. aureus, B. subtilis, E. coli, P. vulgaris, P. aeruginosa, C. albicans, M. lanosum, and T. mentagrophytes with minimum microbicidal concentrations (MMCs) ranging from 0.006 to 0.8% v/v.{52157} Dyclonine (25-100 μM) reduces aldehyde dehydrogenase (ALDH) activity in and viability of HSC-4 oral squamous cell carcinoma cells and enhances HSC-4 and OSC19 cell death induced by sulfasalazine (Item No. 15025).{52158} In vivo, dyclonine (5 mg/kg per day) reduces tumor volume in an HSC-2 mouse xenograft model when administered alone or in combination with sulfasalazine. Dyclonine also induces cerebral frataxin (FXN) production and decreases time to cross and the number of foot slips in a level beam test in a mouse model of Friedreich’s ataxia.{52159}  

 

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SKU: 27667 - 10 g Category:

Description

A topical anesthetic with diverse biological activities; active against various bacteria and fungi (MMCs = 0.006-0.8% v/v); reduces ALDH activity in and viability of HSC-4 cells and enhances sulfasalazine-induced HSC-4 and OSC19 cell death from 25-100 μM; reduces tumor volume in an HSC-2 mouse xenograft model when administered alone or in combination with sulfasalazine at 5 mg/kg; induces cerebral FXN production and decreases time to cross and the number of foot slips in a level beam test in a mouse model of Friedreich’s ataxia

Formal name: 1-(4-butoxyphenyl)-3-(1-piperidinyl)-1-propanone, monohydrochloride

Synonyms:  Dyclone|Dyclothane|Tanaclone

Molecular weight: 325.9

CAS: 536-43-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antifungals||Research Area|Cancer|Cell Death||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Fungal Diseases|Candidiasis||Research Area|Infectious Disease|Fungal Diseases|Ringworm||Research Area|Neuroscience|Neurodegenerative Disorders||Research Area|Neuroscience|Pain Research

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