A noradrenergic neurotoxin; inhibits the uptake of norepinephrine in rat cortical homogenates; reduces dopamine-β-hydroxylase activity in rat brain and selectively depletes norepinephrine in rat cortex and locus coeruleus over the ventral forebrain

DSP-4 – 1 mg

Brand:
Cayman
CAS:
40616-75-9
Storage:
-20
UN-No:
Non-Hazardous - /

DSP-4 is an alkylating agent and a noradrenergic neurotoxin that inhibits the uptake of norepinephrine in rat cortical homogenates.{39935} It reduces dopamine-β-hydroxylase activity in rat brain and selectively depletes norepinephrine in rat cortex and locus coeruleus over the ventral forebrain, hypothalamus, and periphery.{39936,39935} DSP-4 (50 mg/kg) impairs tactile learning in the novel object recognition task in rats.{39937} It also decreases exploration in a novel open area and neophilia in a complex exploration test in rats.{39938}  

 

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Description

A noradrenergic neurotoxin; inhibits the uptake of norepinephrine in rat cortical homogenates; reduces dopamine-β-hydroxylase activity in rat brain and selectively depletes norepinephrine in rat cortex and locus coeruleus over the ventral forebrain, hypothalamus, and periphery; impairs tactile learning in the novel object recognition task in rats at 50 mg/kg; decreases exploration in a novel open area and neophilia in a complex exploration test in rats ,

Formal name: 2-bromo-N-(2-chloroethyl)-N-ethyl-benzenemethanamine, monohydrochloride

Synonyms: 

Molecular weight: 313.1

CAS: 40616-75-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|S6K||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory

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