A STING agonist; induces expression of an ISG54 luciferase reporter in HepAD38 cells that constitutively express human cGAS and STING; increases IFNB1

DSDP – 1 mg

Brand:
Cayman
CAS:
1777807-64-3
Storage:
-20
UN-No:
Non-Hazardous - /

DSDP is an activator of stimulator of interferon genes (STING).{57155} It induces expression of an IFN-stimulated gene 54 (ISG54) luciferase reporter in HepAD38 cells that constitutively express human cyclic GMP-AMP synthase (cGAS) and STING. DSDP (50 µM) increases IFNB1, TNFA, and IL29 expression in HepG2 cells expressing wild-type human, but not C-terminal truncated human or mouse, STING, as well as in isolated human peripheral blood mononuclear cells (PBMCs). It inhibits yellow fever, dengue, and Zika virus replication in THF fibroblasts at the same concentration.  

 

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SKU: 30156 - 1 mg Category:

Description

A STING agonist; induces expression of an ISG54 luciferase reporter in HepAD38 cells that constitutively express human cGAS and STING; increases IFNB1, TNFA, and IL29 expression in HepG2 cells expressing wild-type human, but not C-terminal truncated human or mouse, STING, as well as in isolated human PBMCs at 50 µM; inhibits yellow fever, dengue, and Zika virus replication in THF fibroblasts at 50 µM

Formal name: (5′aS,10′aS)-1′,5′a,6′,10′a-tetrahydro-dispiro[2H-indene-2,3′-[3H,5H,8H,10H]bisthiazolo[3,4-a:3′,4′-d]pyrazine-8′,2″-[2H]indene]-1,1″,3,3″,5′,10′-hexone

Synonyms:  ZINC03129319

Molecular weight: 490.5

CAS: 1777807-64-3

Purity: ≥98%

Formulation: A solid

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