An inhibitor of the mitochondrial calcium uniporter; inhibits calcium uptake by mitochondria isolated from HEK293A cells

DS16570511 – 10 mg

Brand:
Cayman
CAS:
2446154-84-1
Storage:
-20
UN-No:
Non-Hazardous - /

DS16570511 is an inhibitor of the mitochondrial calcium uniporter.{43404} It inhibits calcium uptake by mitochondria isolated from HEK293A cells, rat heart, and pig heart (IC50s = 0.86, 25, and 15 μM, respectively). DS16570511 inhibits fetal bovine serum-induced mitochondrial calcium influx as well as MCU- and MICU1-dependent increases in calcium influx in HEK293A cells (IC50 = 7 μM) but has no effect on mitochondrial membrane potential. Ex vivo, DS16570511 inhibits mitochondrial calcium overload induced by high calcium concentrations in isolated rat hearts. It also reversibly increases cardiac contractility without affecting heart rate.  

 

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SKU: 24160 - 10 mg Category:

Description

An inhibitor of the mitochondrial calcium uniporter; inhibits calcium uptake by mitochondria isolated from HEK293A cells, rat heart, and pig heart (IC50s = 0.86, 25, and 15 μM, respectively); inhibits fetal bovine serum-induced mitochondrial calcium influx as well as MCU- and MICU1-dependent increases in calcium influx in HEK293A cells (IC50 = 7 μM); inhibits mitochondrial calcium overload induced by high calcium concentrations in isolated rat hearts; reversibly increases cardiac contractility without affecting heart rate,

Formal name: 3-[3-[[[3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]methyl]amino]benzoyl]-1H-indole-1-butanoic acid

Synonyms: 

Molecular weight: 562.4

CAS: 2446154-84-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cardiovascular System|Heart|Myocardial Contractility||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization||Research Area|Cell Biology|Mitochondrial Biology

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