An inhibitor of HDAC3

Droxinostat – 10 mg

Brand:
Cayman
CAS:
99873-43-5
Storage:
-20
UN-No:
Non-Hazardous - /

Droxinostat is an inhibitor of histone deacetylase (HDAC) 3, 6, and 8 (IC50s = 16.9, 2.47, and 1.46 μM, respectively).{38617} It is selective for HDAC3, 6, and 8 over HDAC1, 2, 7, 9, and 10 (IC50s = >20 μM). Droxinostat increases histone H3 and H4 acetylation in PPC-1 prostate, OVCAR3 ovarian, U937 leukemia, HT-29 colon, and T47D breast cancer cells. It also inhibits proliferation and colony formation of SMMC-7721 and HepG2 hepatocellular carcinoma cell lines via activation of mitochondrial apoptosis and reduction of cellular FLICE-inhibitory protein (c-FLIP).{38618}  

 

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SKU: 23869 - 10 mg Category:

Description

An inhibitor of HDAC3, HDAC6, and HDAC8 (IC50s = 16.9, 2.47, and 1.46 μM, respectively); selective for HDAC3, 6, and 8 over HDAC1, 2, 7, 9, and 10 (IC50s = >20 μM); inhibits proliferation and colony formation of SMMC-7721 and HepG2 hepatocellular carcinoma cell lines via activation of mitochondrial apoptosis and reduction of c-FLIP,

Formal name: 4-(4-chloro-2-methylphenoxy)-N-hydroxy-butanamide

Synonyms:  NS 41080

Molecular weight: 243.7

CAS: 99873-43-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area

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