An antiarrhythmic agent; inhibits muscarinic acetylcholine receptor-dependent potassium currents induced by carbachol or intracellular loading of GTPγS in single cells isolated from guinea pig atria (IC50s = 0.1 and 1 µM

Dronedarone (hydrochloride) – 100 mg

Brand:
Cayman
CAS:
141625-93-6
Storage:
-20
UN-No:
Non-Hazardous - /

Dronedarone is an antiarrhythmic agent and a derivative of amiodarone (Item No. 15213).{41032,41033} It inhibits muscarinic acetylcholine receptor-dependent potassium currents induced by carbachol (carbamoylcholine; Item No. 14486) or intracellular loading of GTPγS in single cells isolated from guinea pig atria (IC50s = 0.1 and 1 µM, respectively).{41033} Dronedarone (50 and 100 mg/kg) reduces sinus frequency and prolongs action potential duration (APD) in isolated rabbit ventricular myocardium. It increases atrial APD and the atrial effective refractory period (AERP) in a dog model of atrial fibrillation induced by rapid right atrial pacing.{57286} Formulations containing dronedarone have been used in the treatment of atrial fibrillation.  

 

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SKU: 9000543 - 100 mg Category:

Description

An antiarrhythmic agent; inhibits muscarinic acetylcholine receptor-dependent potassium currents induced by carbachol or intracellular loading of GTPγS in single cells isolated from guinea pig atria (IC50s = 0.1 and 1 µM, respectively); reduces sinus frequency and prolongs APD in isolated rabbit ventricular myocardium at 50 and 100 mg/kg; increases atrial APD and the AERP in a dog model of atrial fibrillation

Formal name: N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuranyl]-methanesulfonamide, monohydrochloride

Synonyms:  ,SR33589

Molecular weight: 593.2

CAS: 141625-93-6

Purity: ≥98%

Formulation: A crystalline solid

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