A pro-apoptotic compound and a synthetic analog of dracorhodin; induces cell cycle arrest at the G0/G1 phase as well as apoptosis in U87MG and T98G glioma cells at 40 and 80 μM; increases levels of p53

Dracorhodin Perchlorate – 50 mg

Brand:
Cayman
CAS:
125536-25-6
Storage:
-20
UN-No:
Non-Hazardous - /

Dracorhodin perchlorate is a pro-apoptotic compound and a synthetic analog of dracorhodin, an anthocyanin that has been found in D. draco fruit.{48435,48436} It induces cell cycle arrest at the G0/G1 phase as well as apoptosis in U87MG and T98G glioma cells when used at concentrations of 40 and 80 μM.{48436} It also increases levels of p53, p21, Bim, and Bax and decreases levels of Bcl-2 in glioma cells in vitro. Dracorhodin perchlorate is cytotoxic to U937, A375-S2, and MCF-7 cells in a concentration-dependent manner.{48435} It is also cytotoxic to HeLa cells, an effect that can be reversed by Ac-YVAD-CMK (Item No. 10014), Z-DEVD-FMK (Item No. 14414), Z-IETD-FMK, and Z-LEHD-FMK, which are inhibitors of caspase-1, -3, -8, and -9, respectively.  

 

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SKU: 27294 - 50 mg Category:

Description

A pro-apoptotic compound and a synthetic analog of dracorhodin; induces cell cycle arrest at the G0/G1 phase as well as apoptosis in U87MG and T98G glioma cells at 40 and 80 μM; increases levels of p53, p21, Bim, and Bax and decreases levels of Bcl-2 in glioma cells in vitro; cytotoxic to U937, A375-S2, and MCF-7 cells in a concentration-dependent manner; cytotoxic to HeLa cells, an effect that can be reversed by Ac-YVAD-CMK, A-DEVD-FMK, Z-IETD-FMK, and Z-LEHD-FMK, which are inhibitors of caspase-1, -3, -8, and -9, respectively

Formal name: 7-hydroxy-5-methoxy-6-methyl-2-phenyl-1-benzopyrylium, monoperchlorate

Synonyms: 

Molecular weight: 366.8

CAS: 125536-25-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Cycle|G1||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|p53 Signaling||Research Area|Cancer|Transcription Factors|p53

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