A PARP inhibitor (IC50 = 0.2 and 0.24 µM for PARP1 and PARP2

DR2313 – 10 mg

Brand:
Cayman
CAS:
284028-90-6
Storage:
-20
UN-No:
Non-Hazardous - /

DR2313 is an inhibitor of poly(ADP-ribose) polymerase (PARP; IC50 = 0.2 and 0.24 µM for PARP1 and PARP2, respectively, in nuclear rat brain extracts).{34502} It is selective for PARP, with no effect on GAPDH, ADH, LDH, or on lipid peroxidation. DR2313 is competitive with NAD+ at the catalytic site of PARP with a Ki value of 0.23 µM. Pretreatment of primary rat cortical cultures prevents cell death (EC50 = 0.27 µM), and, in vivo, it reduces infarct volume in a rat model of cerebral ischemia. DR2313 has been used to investigate cell death after middle cerebral artery occlusion.{34503}  

 

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Description

A PARP inhibitor (IC50 = 0.2 and 0.24 µM for PARP1 and PARP2, respectively, in nuclear rat brain extracts); selective for PARP over GAPDH, ADH, or LDH; has no effect on lipid peroxidation; prevents cell death in vitro and in vivo

Formal name: 3,5,7,8-tetrahydro-2-methyl-4H-thiopyrano[4,3-d]pyrimidin-4-one

Synonyms:  PARP Inhibitor XI

Molecular weight: 182.2

CAS: 284028-90-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|DNA Repair Enzymes||Research Area|Cell Biology|Cell Death||Research Area|Neuroscience|Neuroprotection|Ischemia

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