A potent inhibitor of PARPs

DPQ – 1 mg

Brand:
Cayman
CAS:
129075-73-6
Storage:
-20
UN-No:
Non-Hazardous - /

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species.{22577,22591} DPQ is a potent inhibitor of PARPs, inhibiting PARP1 with an IC50 value of 40 nM.{22586} It is approximately 10-fold less potent against PARP2.{22587} DPQ can be used in either cells or in animals.{22588,22589}  

 

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Description

A potent inhibitor of PARPs, inhibiting PARP1 with an IC50 value of 40 nM; about 10-fold less potent against PARP2

Formal name: 3,4-dihydro-5-[4-(1-piperidinyl)butoxy]-1(2H)-isoquinolinone

Synonyms:  PARP Inhibitor III

Molecular weight: 302.4

CAS: 129075-73-6

Purity: ≥99%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors|DNA Repair Enzymes||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis

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