A broad-spectrum tetracycline antibiotic; inhibits bacterial protein synthesis; selectively inhibits human MMP-8 and MMP-13 over MMP-1 with 50

Doxycycline (hyclate) – 1 g

Brand:
Cayman
CAS:
24390-14-5
Storage:
-20
UN-No:
Non-Hazardous - /

Doxycycline is a broad-spectrum tetracycline antibiotic.{42890,22938} It inhibits bacterial protein synthesis by binding to ribosomes.{22938,42891} Doxycycline also selectively inhibits human matrix metalloproteinase-8 (MMP-8) and MMP-13 over MMP-1 with 50, 60, and 5% inhibition, respectively, when used at a concentration of 30 μM.{22936} It can be used as a regulator for inducible gene expression systems where expression depends on either the presence (Tet-On) or absence (Tet-Off) of doxycycline.{22932,22934} Formulations containing doxycycline have been used in the treatment of bacterial infections and the prevention of malaria.  

 

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Description

A broad-spectrum tetracycline antibiotic; inhibits bacterial protein synthesis; selectively inhibits human MMP-8 and MMP-13 over MMP-1 with 50, 60, and 5% inhibition, respectively, at 30 μM; can be used as a regulator for inducible gene expression systems where expression depends on either the presence (Tet-On) or absence (Tet-Off) of doxycycline

Formal name: (4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide, monohydrochloride, monohydrate

Synonyms: 

Molecular weight: 1,025.90

CAS: 24390-14-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Tetracyclines||Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Parasitic Diseases|Malaria

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