A metabolite of doxorubicin; inhibits mitochondrial succinoxidase from bovine heart; reduces the mitochondrial inner membrane potential in rat heart and liver mitochondria; increases pentose phosphate pathway flux by 45% and reduces activity of GPx and SOD by 17 and 60%

Doxorubicinone – 1 mg

Brand:
Cayman
CAS:
24385-10-2
Storage:
-20
UN-No:
Non-Hazardous - /

Doxorubicinone is a metabolite of the anthracycline antitumor antibiotic doxorubicin (Item No. 15007).{22647,37770} Doxorubicinone inhibits mitochondrial succinoxidase from bovine heart and reduces the mitochondrial inner membrane potential in rat heart and liver mitochondria in a concentration-dependent manner.{37771,37772} Doxorubicinone (40 μM) increases pentose phosphate pathway flux by 45% and reduces activity of glutathione peroxidase (GPx) and superoxide dismutase (SOD) by 17 and 60%, respectively, in human erythrocytes.{37773} It also induces cytotoxicity in patient-derived ovarian cancer colonies in a concentration-dependent manner.{37770}  

 

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Description

A metabolite of doxorubicin; inhibits mitochondrial succinoxidase from bovine heart; reduces the mitochondrial inner membrane potential in rat heart and liver mitochondria; increases pentose phosphate pathway flux by 45% and reduces activity of GPx and SOD by 17 and 60%, respectively, in human erythrocytes at 40 μM; induces cytotoxicity in patient-derived ovarian cancer colonies

Formal name: (8S,10S)-7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione

Synonyms:  Adriamycin aglycone|Adriamycinone|aglycone-DOX|Doxorubicin aglycone|Epirubicin aglycone

Molecular weight: 414.4

CAS: 24385-10-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cancer|Cell Death||Research Area|Cell Biology|Mitochondrial Biology

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